![]() Different industries have identified the uses of the combinatorial synthesis method by the 1990s. The N R1, N R2, and N R3 are the numbers of different substituents utilized.īasically, combinatorial chemistry involves the preparation of libraries of a very large number of compounds then, the libraries can be used to identify useful components. For instance, if there is a molecule having three points of diversity known as R1, R2, and R3, it can generate N R1 x N R2 x N R3 possible structures. The pattern of synthesis of molecules using combinatorial synthesis can quickly lead to a large number of molecules. It can be useful for the synthesis of small molecules such as peptides. The branch that studies combinatorial synthesis is known as combinatorial chemistry. These structures are generated by computer software. We can synthesize these compound libraries as mixtures, sets of individual compounds, or chemical structures. The term “large number” in this context might mean tens to thousands or even millions of compounds. Summary – Combinatorial vs Parallel Synthesis What is Combinatorial Synthesis?Ĭombinatorial synthesis is the chemical synthesis method that enables preparing a large number of compounds in a single process. Combinatorial vs Parallel Synthesis in Tabular Formĥ. Parallel synthesis is an important technique that can be used to accelerate the discovery of new compounds and to screen for optimal process conditions. The key difference between combinatorial and parallel synthesis is that combinatorial synthesis use mixtures of compounds for reactions, whereas parallel synthesis uses an individual compound for reactions.Ĭombinatorial synthesis is the chemical synthesis method that can make it possible to prepare a large number of compounds in a single process.
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